lonza employee places flipped horseshoe crab at shoreline

At Lonza, we are aware of the importance of the horseshoe crab for its contribution to the safety of drugs and medical devices, but also its ecological role.

We committed to protecting the welfare of the horseshoe crab through adopting best practices and actively supporting conservation efforts.

Read more about how FDA and USP Can Help Promote Horseshoe Crab Conservation     


2016 Endotoxin Summit attendee places flipped
horseshoe crab at shoreline 


Subscribe to QC Testing e-News & Donate to ERDG

Female horseshoe crab returns to the sea
   Our quarterly e-Newsletter provides you with the latest information on endotoxin detection products, services and software. Our featured content includes new items added to our QC Insider™ Toolbox, technical tips, white papers, special events, webinars, and exclusive news items.  

For each subscription, a $1.00 donation will be made to ERDG, the Ecological Research & Development Group, a non-profit wildlife conservation organization whose primary focus is the conservation of the world’s four remaining horseshoe crab species.  

Subscribe to QC Testing e-News



Sponsorship Activities

Lonza will continue sponsorship of horseshoe crab conservation initiatives developed by the Ecological Research and Development Group (ERDG) throughout 2018 to help raise conservation awareness. With sponsorship money, ERDG will be able to:  

  • Broaden the functionality of their Horseshoe Crab Teacher Toolbox. Launched in 2015, it is an online library for educators from around the world to share lesson plans, print materials and audio-visual resources
  • Initiate a project to eliminate the use of Limulus polyphemus as bait in conch and eel fishing, for example, by implementing bait saving gear and developing alternative baits


A Biomedical Gift

Horseshoe crabs play an important role to play in the pharmaceutical industry for endotoxin testing. The ameobyctes, or blood cells, of the horseshoe crab contain a clotting agent that forms in the presence of Gram-negative bacteria. Limulus Amebocyte Lysate (LAL) is derived from the blood cells of the horseshoe crab and is used in Quality Control (QC) tests to detect endotoxin in pharmaceutical and medical device products. These QC tests help ensure human and animal intravenous drugs, vaccines and medical devices are safe for patient use.  

Our Commitment to Sustainability

Lonza is committed to protecting the horseshoe crab through adopting best practices and actively supporting conservation efforts.

  • Our Global Endotoxin Summit includes travel to a horseshoe crab sanctuary beach where attendees help save horseshoe crabs that have been stranded as a result of spawning activities, supporting ERDG’s      Just flip em® Program
  • Lonza does not sell the horseshoe crabs that we use for biomedical purposes after bleeding; they are returned alive to the same waters from which they were taken
  • A senior member of our staff sits on the Atlantic States Marine Fisheries Commission (ASMFC) Technical Committee for the horseshoe crab and is also the biomedical industry representative on the joint team of the ASMFC and the Shorebirds Commission. Both groups are active in promoting the preservation of the horseshoe crab
  • Annually, we donate funds and products to support educational programs about the horseshoe crab and also help coastal communities save the breeding and nursery grounds for the horseshoe crabs
  • Our commercially available PyroGene™ rFC Assay uses a recombinant form of the horseshoe crab      Factor C to detect endotoxin. The PyroGene™ Assay does not use horseshoe crab blood as the raw material, therefore, there is less dependence on the animal, which results in less animal utilization. The    use of an alternative method reduces the demand on a natural resource and can help meet supply chain sustainability initiatives

We strive to protect the future generations of the horseshoe crab through our commitment to employ the best practices when handling horseshoe crabs used in the manufacture of LAL, and through our continued sponsorship of ERDG’s conservation projects.   

For more information about horseshoe crabs, visit ERDG’s Facebook page.